INiclosamide yisalicylanilide eneklorini efumaneka ngomlomo, ene-anthelmintic kunye nomsebenzi onokubakho we-antineoplastic.Ekulawuleni ngomlomo, i-niclosamide ibangela ngokukodwa ukuthotywa kwe-androgen receptor (AR) i-V7 (AR-V7) ngendlela ye-proteasome-mediated pathway.Oku kunciphisa ukubonakaliswa kwenguqu ye-AR, inqanda umsebenzi we-AR-V7-mediated transcriptional, kwaye inciphisa ukuqeshwa kwe-AR-V7 kwi-prostate-specific antigen (PSA) umgqugquzeli wofuzo.I-Niclosamide ikwakhusela i-AR-V7-mediated STAT3 phosphorylation kunye nokusebenza.Oku kuthintela ukubonakaliswa kwe-AR/STAT3-mediated kwaye kuthintela ukubonakaliswa kwe-STAT3 yejini ekujoliswe kuyo.Lilonke, oku kunokuthintela ukukhula kweeseli zomhlaza ze-AR-V7-overexpressing.Ukwahluka kwe-AR-V7, efakwe ngekhowudi ngokuqhekeka okudibeneyo kwe-AR exons 1/2/3/CE3, ilawulwa kwiindidi zeeseli zomhlaza, kwaye inxulunyaniswa nokuqhubela phambili komhlaza kunye nokuchasana nonyango olujoliswe yi-AR.

Ukuqulunqwa:

Nganye bolus cotnains 1250 mg niclosamide

Isalathiso:

Kwizilwanyana ezosulelwa yiparamphistomes, cestodiasis, ezifana neenkomo kunye neegusha moniezia, avitellina centripunctata, njl.

Umthamo kunye nokusetyenziswa:

Ngomlomo ngamnye 1kg ubunzima bomzimba.

Iinkomo: 40-60mg

Iigusha: 60-70mg

Ixesha lokurhoxisa:

Iigusha: iintsuku ezingama-28.

Iinkomo: iintsuku ezingama-28.

Ubungakanani bepakethi: i-tablet ye-5 nge-blister, i-blister eyi-10 ngebhokisi